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A natural quinazoline derivative from marine sponge hyrtios erectus induces apoptosis of breast cancer cells via ROS production and intrinsic or extrinsic apoptosis pathways

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10.20517/2394-5079.2020.96 Summary Keywords non-alcoholic fatty liver disease, oxidative stress, antioxidants, obstructive sleep apnea syndrome, gut microbiota, obesity, metabolic syndrome Citation Delli Bovi AP, Marciano F, Mandato C, Siano MA, Savoia M and Vajro P (2021) Oxidative Stress in Non-alcoholic Fatty Liver Disease

This high metabolic rate leads to increased production of reactive oxygen species (ROS) as byproducts of cellular respiration.Presence of Redox-Active Metals: The brain contains transition metals such as iron and copper, which can catalyze the formation of highly reactive hydroxyl radicals through the Fenton reaction.Limited Regenerative Capacity: Unlike some other tissues, neurons have limited regenerative capacity